This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 2 diabetes is associated with damage, dysfunction, and failure of various organs. The coexistence of diabetes and hypertension is particularly damaging to cardiac and peripheral vascular structure and function. Although exercise is often endorsed as a therapeutic modality for type 2 diabetes, most studies of exercise and diabetes have focused upon glycemic control, rather than cardiovascular health. Although exercise lowers blood pressure in hypertensive individuals without diabetes, there are significant gaps in the knowledge regarding the effects of exercise training on blood pressure and cardiovascular health in persons with type 2 diabetes. The primary specific aim of this protocol is to determine if exercise training reduces blood pressure in persons who have both type 2 diabetes and high normal blood pressure or mild hypertension. In addition, the effects of exercise training on parameters of cardiac and peripheral vascular structure related to cardiovascular disease in diabetes and hypertension will be determined.
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