This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.ADHD is a common neuropsychiatric disorder that affects 3-7% of school age children and 1-5% of adults. Psychomotor stimulant drugs such as amphetamine are the mainstay of therapy. Preclinical data have suggested that amphetamine may damage dopaminergic neurons in animals. Moreover, there is now evidence in baboons and squirrel monkeys that amphetamine doses equivalent to those used treat ADHD lead to dopamine neurotoxicity. The purpose of this study is to assess the status of brain dopaminergic neurons in adults with ADHD using PET with [11C]WIN3652, a radioligand selective for the dopamine transporter, and [11C]DTBZ, a radioligand selective for the vesicular monoamine transporter. The investigators hypothesize that adults with ADHD treated with amphetamines will have reductions in both dopamine markers compared to adults who have not previously received amphetamines.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR002719-22
Application #
7607487
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-12-01
Project End
2007-09-16
Budget Start
2006-12-01
Budget End
2007-09-16
Support Year
22
Fiscal Year
2007
Total Cost
$1,028
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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