The purposes of this study are to determine the maximum tolerated dose of L-buthionine sulfoximine (BSO) given as a bolus and continuous infusion in conjunction with a bolus of melphalan (L-PAM), determine pharmacokinetics and pharmacodynamics of BSO, to explore biochemical effects of BSO and L-PAM on GSH metabolism, and to assess toxicities of BSO and L-PAM.

Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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