Effect of Diabetes Mellitus and Peritoneal Dialysis on Pk of Cefpodoxime

Johnson, Curtis A.

Abstract

A previous study in CAPD patients demonstrated a delay in absorption following oral administration of cefpodoxime proxetil, suggesting CAPD patients experience a delay in gastric emptying of digestible solids. This could have important dosing implications for other orally administered drugs. This study will evaluate the relative importance of the presence of dialysis fluid in the peritoneum and gastroparesis associated with DM on the gastric emptying of digestible solids and the PK of cefpodoxime proxteil in CAPD patients.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: General Clinical Research Centers Program (M01)
• Project #: 2M01RR003186-10
• Application #: 3744613
• Support Year: 10
• Fiscal Year: 1995

Institution

• Name: University of Wisconsin Madison
• DUNS #: 161202122
• City: Madison
• State: WI
• Country: United States
• Zip Code: 53715

Publications

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Kelly, Elizabeth A; Esnault, Stephane; Johnson, Sean H et al. (2016) Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF. Immunol Cell Biol 94:701-8

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Lee, Yong Gyu; Jeong, Jong Jin; Nyenhuis, Sharmilee et al. (2015) Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma. Am J Respir Cell Mol Biol 52:772-84