This study will determine if pretreatment with amifostine increases the therapeutic index of cisplatin when combined with vinblastine in the treatment of patients with Stage IV non-small cell lung cancer. Increased therapeutic index is defined as increased antitumor efficacy and/or reduced toxicity (nephrotoxicity and/or neurotoxicity and/or ototoxicity) at comparable doses of cisplatin with no reduction in antitumor efficacy. Preclinical data suggest that the addition of amifostine to cisplatin and vinblastine has the potential to increase the therapeutic index of this regimen in the treatment of patients with Stage IV non-small cell lung cancer either by potentiating its antitumor activity and/or reducing the toxicity. This is the hypothesis to be tested in this Phase III trial.

Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
15
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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