This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. [from CRISP website (edited)] Sleep disordered breathing (SDB), is a widespread but under-diagnosed condition that may have a role in causing hypertension, cardiovascular, and cerebrovascular disease, hypersomnolence, and lower daytime functioning. However, findings thus far are not enough for determining rational clinical and public health responses. The long-term objective of this project is to determine how much morbidity and mortality from SDB could potentially be reduced with prevention or treatment of SDB. Because SDB is a chronic and severe condition and the health effects may take years to develop, samples over a period of time are essential. Also, SDB is high in middle age, but the long-term outcomes are conditions primarily occuring in older age ( 60 years), requiring data on individuals as they move from middle to older age to validly estimate the morbidity risks attributable to SDB. Currently these data are lacking; this research proposed addresses the gap in understanding the burden of undiagnosed SDB in adults. We will investigate the role of SDB in oreclinical cardiovascular and cerebrovascular disease (CVD/stroke), incident CVD/stroke, mortality and in chronic daytime dysfunction. We will also investigate changes in SDB occurrence and its effects with aging from middle to older age. We are doing research on a subsample of 500 men and women who will transition from middle to older age ( 60 years) during the 5 years of the study. All minority participants enrolled in the Wisconsin Sleep Cohort Study (WSCS) will be recruited for both exams, regardless of age. We will assess the independent contribution of SDB to preclinical and overt CVD/stroke, hypersonmolence, cognitive function, occupational injury, depression and quality of life.
| Burgess-Hull, Albert J; Roberts, Linda J; Piper, Megan E et al. (2018) The social networks of smokers attempting to quit: An empirically derived and validated classification. Psychol Addict Behav 32:64-75 |
| Kelly, Elizabeth A; Esnault, Stephane; Liu, Lin Ying et al. (2017) Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma. Am J Respir Crit Care Med 196:1385-1395 |
| Shen, Zhong-Jian; Hu, Jie; Kashi, Venkatesh P et al. (2017) Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways. Am J Respir Crit Care Med 195:1576-1585 |
| Anderson, Halie M; Lemanske Jr, Robert F; Evans, Michael D et al. (2017) Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk. J Allergy Clin Immunol 139:692-694 |
| Gomez, Jose L; Yan, Xiting; Holm, Carole T et al. (2017) Characterisation of asthma subgroups associated with circulating YKL-40 levels. Eur Respir J 50: |
| Kelly, Elizabeth A; Esnault, Stephane; Johnson, Sean H et al. (2016) Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF. Immunol Cell Biol 94:701-8 |
| Bray, Bethany C; Smith, Rachel A; Piper, Megan E et al. (2016) Transitions in Smokers' Social Networks After Quit Attempts: A Latent Transition Analysis. Nicotine Tob Res 18:2243-2251 |
| Dougherty, Ryan J; Ellingson, Laura D; Schultz, Stephanie A et al. (2016) Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease. Alzheimers Dement (Amst) 4:14-7 |
| Johansson, Mats W; Evans, Michael D; Crisafi, Gina M et al. (2016) Serum periostin is associated with type 2 immunity in severe asthma. J Allergy Clin Immunol 137:1904-1907.e2 |
| Gerald, Joe K; Gerald, Lynn B; Vasquez, Monica M et al. (2015) Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma. J Allergy Clin Immunol Pract 3:540-6.e3 |
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