Abstract

The objective of the proposal is to determine what benefits estrogen replacement would have on cardiovascular risk factors, lipoprotein oxidation, glycemic control, and postprandial triglyceride concentrations in women with type II diabetes mellitus. Fifty postmenopausal women with type II diabetes will be treated with conjugated equine estrogen 0.625 mg/d and a placebo in a randomized crossover design, each for a duration of 8 weeks. At the end of the placebo and estrogen phases, duplicate lipoprotein profiles, apolipoproteins A-I and B, lipoprotein (a), fasting glucose, and glycosylated hemoglobin concentrations will be obtained. Lipoprotein fractions (VLDL, LDL, and HDL) will be isolated by sequential ultracentrifugation, then analyzed for lipoprotein oxidation, and the susceptibility of lipoprotein to further oxidation. The effect of estrogen on postprandial triglyceridemia will be tested by quantifying the plasma triglyceride excursion after a liquid fatty meal.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR005096-07
Application #
5224990
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Kempen, John H; Sugar, Elizabeth A; Varma, Rohit et al. (2014) Risk of cataract among subjects with acquired immune deficiency syndrome free of ocular opportunistic infections. Ophthalmology 121:2317-24
Ricardo, Ana C; Yang, Wei; Lora, Claudia M et al. (2014) Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study. Clin Nephrol 81:30-7
Kozak, Igor; Vaidya, Vijay; Van Natta, Mark L et al. (2014) The prevalence and incidence of epiretinal membranes in eyes with inactive extramacular CMV retinitis. Invest Ophthalmol Vis Sci 55:4304-12
Wing, Maria R; Devaney, Joseph M; Joffe, Marshall M et al. (2014) DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 29:864-72
Mariani, Laura H; White, Matthew T; Shults, Justine et al. (2014) Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. J Ren Nutr 24:186-93
Wing, Maria R; Yang, Wei; Teal, Valerie et al. (2014) Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring) 22:1359-66

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