The field of antiretroviral therapy has evolved rapidly. The high rate of viral turnover has provided the rationale for aggressively treating HIV-1 infected individuals with the most potent regimens available. Thus, the direction of the field is to try to develop combinations of agents which will suppress plasma HIV-1 RNA concentrations to below the limits of detection of currently available assays. Studies of a number of different combinations drawn from the protease inhibitor, nucleoside analog reverse transcriptase inhibitor and non-nucleoside reverse transcriptase inhibitor classes of compounds have been able to achieve this goal for variable durations in the majority of subjects studied. Therefore, this study aims to study the prolongation of virologic success and options for virologic failure in HIV-infected subjects who are receiving indinavir plus nucleoside analogs.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR005096-10A1
Application #
6265773
Study Section
Project Start
1999-07-19
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
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