This is a randomized, double-blinded study of the treatment of candidemia and its consequences in non-neutropenic patients, comparing the efficacy, tolerance, and safety of fluconazole to that of fluconazole plus amphotericin B. Fluconazole is a novel orally effective triazole antifungal agent. It has been found to be effective in models of fungal infection in both normal and immunocompromised animals, including experimental cryptococcosis of mice and rabbits and murine candidiasis and histoplasmosis. In addition, human studies involving AIDS patients with CNS cryptococcus and non-neutropenic patients with systemic candidiasis also demonstrate clinical efficacy of fluconazole. In animal studies, fluconazole usually has not eradicated the fungus from all tissues, as can be accomplished with amphotericin B, but it has significantly prolonged life and decreased tissue burden of pathogenic fungi. In this respect, fluconazole resembles imidazoles and other triazoles.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR005096-10A1
Application #
6265776
Study Section
Project Start
1999-07-19
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
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