Abstract

One of the many complications associated with diabetes is peripheral neuropathy, which may affect up to 90% of diabetic patients with about 25% having clinical signs or symptoms. Diabetic peripheral neuropathy is defined as nerve damage attributable solely to diabetes mellitus; it can be either clinically evident or subclinical in nature and may involve the somatic and/or autoimmune nervous systems. The peripheral neuropathies are generally progressive and usually irreversible and often progress to a severe loss of sensation in the lower extremities, a condition that leads to an increased incidence of foot ulcers, infections, and amputations. The purpose of this study is to determine if CI-1014 (zenarestat), an aldose reductase inhibitor, can reverse, stabilize, or slow the progression of diabetic neuropathy relative to placebo and to assess the safety of CI-1014.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR005096-11
Application #
6411386
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1990-01-14
Project End
2001-11-30
Budget Start
Budget End
Support Year
11
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118

  Publications

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Rahman, Mahboob; Xie, Dawei; Feldman, Harold I et al. (2014) Association between chronic kidney disease progression and cardiovascular disease: results from the CRIC Study. Am J Nephrol 40:399-407
Kempen, John H; Sugar, Elizabeth A; Varma, Rohit et al. (2014) Risk of cataract among subjects with acquired immune deficiency syndrome free of ocular opportunistic infections. Ophthalmology 121:2317-24
Ricardo, Ana C; Yang, Wei; Lora, Claudia M et al. (2014) Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study. Clin Nephrol 81:30-7
Kozak, Igor; Vaidya, Vijay; Van Natta, Mark L et al. (2014) The prevalence and incidence of epiretinal membranes in eyes with inactive extramacular CMV retinitis. Invest Ophthalmol Vis Sci 55:4304-12
Wing, Maria R; Devaney, Joseph M; Joffe, Marshall M et al. (2014) DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 29:864-72
Mariani, Laura H; White, Matthew T; Shults, Justine et al. (2014) Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. J Ren Nutr 24:186-93
Wing, Maria R; Yang, Wei; Teal, Valerie et al. (2014) Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring) 22:1359-66

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