Abstract

The new compound MKC-442 is an NNRTI which has demonstrated potent in vitro activity against HIV-1 both as a single agent and in combination with other anti-HIV drugs. Data from in vitro studies have demonstrated antiretroviral activity of MKC-442 against various strains of HIV-1, including clinical isolates and strains with reduced sensitivity to ZDV. In the laboratory, combinations of MKC-442 with ddI produced moderate synergy while combination with ddC was additive in inhibiting HIV-1 infection. When used in combination with ZDV or with ZDV and saquinavir, impressive synergistic inhibition of HIV-1 replication was observed. When MKC-442 was combined with ZDV and 3 TC, the drugs synergistically suppressed HIV-1 replication in MT-4 cells over a wide range of doses. Since in vitro evidence indicates that strains of HIV-1 with reduced sensitivity to MKC-442 can emerge upon exposure to MKC-442 as a single agent, MKC-442 would be most effectively used in combination with other agents in the treatment of HIV-1 antiviral agents in the long-term treatment of HIV disease. This protocol aims to study the efficacy, safety, and tolerability of a combination of MKC-442 Viracept in the background of either stavudine (d4T) plus lamivudine (3TC) or stavudine (d4T) plus didanosine (ddI).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR005096-12
Application #
6458599
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
12
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118

  Publications

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Chyun, Deborah A; Wackers, Frans J Th; Inzucchi, Silvio E et al. (2015) Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study. SAGE Open Med 3:2050312114568476
Ricardo, Ana C; Yang, Wei; Lora, Claudia M et al. (2014) Limited health literacy is associated with low glomerular filtration in the Chronic Renal Insufficiency Cohort (CRIC) study. Clin Nephrol 81:30-7
Kozak, Igor; Vaidya, Vijay; Van Natta, Mark L et al. (2014) The prevalence and incidence of epiretinal membranes in eyes with inactive extramacular CMV retinitis. Invest Ophthalmol Vis Sci 55:4304-12
Wing, Maria R; Devaney, Joseph M; Joffe, Marshall M et al. (2014) DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 29:864-72
Mariani, Laura H; White, Matthew T; Shults, Justine et al. (2014) Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. J Ren Nutr 24:186-93
Wing, Maria R; Yang, Wei; Teal, Valerie et al. (2014) Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring) 22:1359-66
Belzer, Marvin E; Naar-King, Sylvie; Olson, Johanna et al. (2014) The use of cell phone support for non-adherent HIV-infected youth and young adults: an initial randomized and controlled intervention trial. AIDS Behav 18:686-96
Rahman, Mahboob; Xie, Dawei; Feldman, Harold I et al. (2014) Association between chronic kidney disease progression and cardiovascular disease: results from the CRIC Study. Am J Nephrol 40:399-407

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