This is a proposal to establish a General Clinical Research Center (GCRC) at the University of Miami/Jackson Memorial Hospital Medical Center. The primary function of the GCRC will 1. To promote and enhance higher quality and more efficient and productive and clinical investigation. 2. Create a nucleus around which pre and postdoctoral training and educational programs can be developed and strengthened. 3. Facilitate the cross fertilization and interaction of basic scientists with clinical faculty. 4. Provide an ideal environment in which medical students, housestaff, fellows, and junior faculty can stimulated to formulate their own research ideas and career objectives. The physical facility will consist of an eight-bed unit, six beds on SW 6 and two in the AIDS unit located on NW 3 to be used for AIDS-related research; an outpatient facility in the same geographic area, a core laboratory, a metabolic kitchen, nurses station, conference room, room for potential CLINFO System, a room for students, housestaff and fellows, and offices or the program director, associate director, and administrator. The center will be strategically located in proximity to the main stream of clinical activities including ward medicine and surgery, the intensive care unit, the coronary care unit, radiology, pathology and other ancillary facilities. The center will be jointly operated by the UM and JMH based both on mutual academic and fiscal commitments and responsibilities. The use of the center will be open to all disciplines in the medical center. Clinical investigation protocols include in this proposal come from Endocrine-Metabolism, Diabetes, Nephrology, Cardiology, Hepatology, Surgery, Neonatology, Psychiatry, Hematology, Psychology, and Oncology. Collaborative interaction with the basic sciences is evident particularly with the Department of Microbiology and Immunology, and is likely to grow rapidly. Some of the history and recent developments at the UM/JMH center, relevant to this application, are briefly reviewed with emphasis on the following points: 1. Almost unparalleled growth Of the UM/JMH medical center both as a medical and research institution. 2. Extraordinary increase in the quantity and quality of biomedical research at the School. 3. Recent surge in the quality of the basic sciences and the number of collaborative programs between basic scientists and clinical faculty. It is our earnest conviction that the establishment of a GCRC has become critical to further academic growth of this medical center.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
General Clinical Research Centers Committee (CLR)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Miami School of Medicine
Schools of Medicine
United States
Zip Code
Puhan, Milo A; Ahuja, Alka; Van Natta, Mark L et al. (2011) Interviewer versus self-administered health-related quality of life questionnaires - does it matter? Health Qual Life Outcomes 9:30
Puhan, Milo A; Van Natta, Mark L; Palella, Frank J et al. (2010) Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors. Clin Infect Dis 51:947-56
Rimrodt, Sheryl L; Peterson, Daniel J; Denckla, Martha B et al. (2010) White matter microstructural differences linked to left perisylvian language network in children with dyslexia. Cortex 46:739-49
Johnson, Andrew D; Yanek, Lisa R; Chen, Ming-Huei et al. (2010) Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet 42:608-13
Wilkin, Timothy J; Su, Zhaohui; Krambrink, Amy et al. (2010) Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients. J Acquir Immune Defic Syndr 54:470-6
Gluckman, T J; Segal, J B; Schulman, S P et al. (2009) Effect of anti-platelet factor-4/heparin antibody induction on early saphenous vein graft occlusion after coronary artery bypass surgery. J Thromb Haemost 7:1457-64
Cole, W R; Mostofsky, S H; Larson, J C Gidley et al. (2008) Age-related changes in motor subtle signs among girls and boys with ADHD. Neurology 71:1514-20
Froud, Tatiana; Faradji, Raquel N; Pileggi, Antonello et al. (2008) The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation 86:36-45
Jabs, Douglas A; Van Natta, Mark L; Holbrook, Janet T et al. (2007) Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment. Ophthalmology 114:780-6
Jabs, Douglas A; Van Natta, Mark L; Holbrook, Janet T et al. (2007) Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment. Ophthalmology 114:787-93

Showing the most recent 10 out of 38 publications