Abstract

DMHP (Deferiprone) is a potentially useful oral iron chelating agent. We are conducting metabolic iron balance studies wherein the efficacy of DMHP is being compared with that of DFO infused subcutanelously. Thus far studies have been conducted in 6 patients 3 male, 3 female showing that DMHP is approximately 40% as effective as DFO in terms or iron excretion. While DMHP is less effective then DFO it is nontheless capable of placing 5 of 6 patients in net negative iron balance is a useful substitute for DFO in chelation therapy DMHP (Deferiprone) is a potentially useful oral iron chelating agent. We are conducting metabolic iron balance studies wherein the efficacy of DMHP is being compared with that of DFO infused subcutanelously. Thus far studies have been conducted in 6 patients 3 male, 3 female showing that DMHP is approximately 40% as effective as DFO in terms or iron excretion. While DMHP is less effective then DFO it is nontheless capable of placing 5 of 6 patients in net negative iron balance is a useful substitute for DFO in chelation therapy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR006020-08S1
Application #
6282583
Study Section
Project Start
1997-01-06
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Cunningham-Rundles, Susanna; Ahrné, Siv; Johann-Liang, Rosemary et al. (2011) Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients 3:1042-70
Martin, Maureen P; Qi, Ying; Goedert, James J et al. (2010) IL28B polymorphism does not determine outcomes of hepatitis B virus or HIV infection. J Infect Dis 202:1749-53
Cunningham-Rundles, Susanna; Lin, Hong; Ho-Lin, Deborah et al. (2009) Role of nutrients in the development of neonatal immune response. Nutr Rev 67 Suppl 2:S152-63
Peoples, John Denton; Cheung, Sandy; Nesin, Mirjana et al. (2009) Neonatal cord blood subsets and cytokine response to bacterial antigens. Am J Perinatol 26:647-57
Tatad, A M Francesca; Nesin, Mirjana; Peoples, John et al. (2008) Cytokine expression in response to bacterial antigens in preterm and term infant cord blood monocytes. Neonatology 94:8-15
Thio, Chloe L; Astemborski, Jacquie; Thomas, Rasmi et al. (2008) Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. J Immunol 181:7944-7
Thio, Chloe L; Astemborski, Jacquie; Bashirova, Arman et al. (2007) Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence. J Virol 81:441-5
Motaghedi, Roja; Gujral, Sahil; Sinha, Sunil et al. (2007) Insulin-like growth factor binding protein-1 to screen for insulin resistance in children. Diabetes Technol Ther 9:43-51
Diaz, Alejandro; Vogiatzi, Maria G; Sanz, Maureen M et al. (2006) Evaluation of short stature, carbohydrate metabolism and other endocrinopathies in Bloom's syndrome. Horm Res 66:111-7
Vogiatzi, Maria G; Autio, Karen A; Mait, Jeffrey E et al. (2005) Low bone mineral density in adolescents with beta-thalassemia. Ann N Y Acad Sci 1054:462-6

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