The prevalence of type 2 diabetes is increasing dramatically in minority adolescents in association with the increased frequency of obesity. Nevertheless, carefully controlled studies of the use of oral hypoglycemic agents have not been performed in youth with type 2 diabetes. An oral agent, Metformin, for glucose control will be studied in children with type 2 diabetes. The use of Metformin with insulin is being compared to the use of insulin alone. If the Metformin has a beneficial effect, then the insulin will be tapered to off if feasible. This study is being conducted in cooperation with the Yale Pediatric Pharmacology Research Unit (PPRU)and the NICHD PPRU network.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR006022-11
Application #
6406232
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1989-12-01
Project End
2003-11-30
Budget Start
Budget End
Support Year
11
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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