This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Prostheses placed over dental implants are generally made with a metal substructure supporting either a ceramic veneer or resin with artificial plastic teeth. The use of fiber composite technology in the creation of a metal-free implant prosthesis may solve many of the problems associated with this metal alloy substructure such as corrosion, toxicity, complexity of fabrication, high cost and esthetic deficiencies.Glass fiber-reinforced composites (FRCs) have been developed which have the potential to make an esthetic implant prosthesis substructure utilizing a simple, time-efficient technique. Laboratory and clinical research evaluating FRC prostheses used to restore and replace teeth have shown that these materials exhibit excellent mechanical properties and can form a chemical bond to resin-based veneer materials. Additionally, these FRC materials have the potential to be used to make a single visit, chairside-fabricated provisional tooth replacement bonded to an adjacent anterior tooth prior to implant loading.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR006192-15
Application #
7719088
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-04-01
Project End
2009-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
15
Fiscal Year
2008
Total Cost
$6,140
Indirect Cost
Name
University of Connecticut
Department
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53
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