This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The overall goal of this research is to improve treatment outcome for marijuana-dependent individuals. The study will attempt to enhance abstinence over the levels obtained in prior research by combining contingency management with Motivational Enhancement Therapy and Cognitive Behavior Therapy (MET/CBT), providing voucher-based reinforcement for abstinence. This combined intervention will be compared to three other interventions: MET/CBT-only, contingency-management-only, and a control group that receives supportive case management only. Recruitment of 260 marijuana-dependent participants will occur over a three-year period. They will be randomly assigned to one of the four interventions. All treatments will be individual, manualized, and provided on an outpatient basis for 9-sessions. Pretreatment assessments will provide baseline data against which to compare treatment outcomes. Follow-up assessments, at three-month intervals for one year following treatment, will evaluate marijuana and other drug/alcohol use, and psychosocial functioning in several domains. It is anticipated that the intervention combining contingency management and MET/CBT will result in the best outcomes, and that the contingency management and MET/CBT interventions by themselves will each be superior to supportive case management.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR006192-15
Application #
7719091
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-04-01
Project End
2009-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
15
Fiscal Year
2008
Total Cost
$89,648
Indirect Cost
Name
University of Connecticut
Department
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53
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