This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.1. To obtain pilot data on 4-week continuous quit rates associated with either 12 weeks of treatment with topiramate alone or topiramate in combination with 10 weeks of nicotine patch for smoking cessation.2. To obtain pilot data on the effects of 12 weeks of topiramate alone or topiramate combined with 10 weeks of nicotine patch, on nicotine withdrawal symptoms, smoking satisfaction, and adverse effects during smoking cessation.3. To obtain pilot data on weight gain over 12 weeks with either topiramate alone or topiramate in combination with the nicotine patch.
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