This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This project is designed to examine the molecular mechanism underlying suicidal death in tumor antigen specific cytolytic T lumphocytes (CTL) when they re-encounter antigen and to examine how such deaths in the CTL can be prevented so as to orchestrate a robust and long-lived CTL response during cancer immunotherapy. The studies will be done in ex-vivo laboratory experiments and in animals bearing grafts of human melanoma cells.
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