This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This project is designed to examine the molecular mechanism underlying suicidal death in tumor antigen specific cytolytic T lumphocytes (CTL) when they re-encounter antigen and to examine how such deaths in the CTL can be prevented so as to orchestrate a robust and long-lived CTL response during cancer immunotherapy. The studies will be done in ex-vivo laboratory experiments and in animals bearing grafts of human melanoma cells.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR006192-15
Application #
7719159
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-04-01
Project End
2009-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
15
Fiscal Year
2008
Total Cost
$7,778
Indirect Cost
Name
University of Connecticut
Department
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
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