It is possible that in patients with persistent fasting hyperglycemia, sulfonylureas may increase peripheral tissue insulin sensitivity resulting in improved tolerance and a reduction in fasting and postprandial glucose. With the development of techniques to specifically assess tissue glucose disposal, this question can be addressed. Dr. Cefalu's study is evaluating the effects of a second-generation sulfonylurea versus placebo in altering peripheral tissue insulin resistance in non-insulin dependent diabetes.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
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