Human polymorphonuclear leukocytes (PMNL) synthesize, secrete, and contain specific membrane receptors for, and respond to, the cytokines II-1 alpha and beta and TNF-beta. Both of these cytokines and PMNL play an essential role in the pathogenesis of acute disseminated inflammation with organ failure which may follow microbial infection (septic shock). Dr. McCall's objective is is to show that septic shock in humans is consistently associated with amplified expression of the IL-1 beta gene.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
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