This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Soybeans and other legumes contain large amounts of plant estrogens known as isoflavones. These isoflavones have the potential to shrink prostate volume and reduce the progression of latent prostate cancers. In Asian countries like Japan, where soy consumption is high, prostate cancer rates are lower than in Western countries with low soy intake. Since we do not know conclusively how soy will affect the prostate, we are proposing to conduct a pilot study which will allow for the determination of the effects of soy on markers of prostate cancer risk. This study will enroll 160 men (80 white men and 80 African-Amerian men) aged 50 and older who have high PSA levels but normal prostate biopsies in a clinical trial examining the effects of soybean supplements on clinical and intermediate tumor markers of prostate cancer risk. Other objectives will focus on the effects of soy on urinary and sexual functioning.
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