This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ductal carcinoma in situ (DCIS) is a form of non-invasive breast cancer that currently accounts for 15-20% of all breast cancers. Although the incidence rate of DCIS is on the rise, little is known about how the diagnosis and treatment of DCIS impacts psychological and physical function or how these outcomes compare to those for women diagnosed with more advanced stages of breast cancer. Declines in physical activity and physical function have been noted due to breast cancer diagnosis and treatment. Although preliminary studies suggest that physical activity may be especially important for women with breast cancer, women with DCIS have not been targeted for participation in studies that examine the role that exercise may play in the recovery process. The proposed study will assess the physical function and health-related quality of life of women treated for DCIS and determine if a moderate, tailored exercise intervention, as compared to enhanced usual care, significantly improves physical outcomes, including cardiorespiratory endurance, muscular strength and flexibility, and HRQL in women with DCIS. Secondary aims of this study include comparing DCIS participants with women diagnosed with stage I-III breast cancer recruited for a larger prospective trial to describe differences in severity of diagnosis, effects of the exercise intervention, total energy and nutrient intake profiles, and intervention compliance. These data will be used to formulate recommendations for the rehabilitation of women with DCIS and for the submission of a federally funded study.
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