This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As the life expectancy of older Americans increases, prevention of age-associated physical function decline and disabilities has emerged as a major clinical and public health priority. A critical factor in an older person's ability to function independently is mobility, the ability to move without assistance. Older people who lose mobility are less likely to remain in the community, have higher rates of illness, death and hospitalizations, and experience a poorer quality of life. While several studies suggest that physical activity may prevent physical disability, including mobility disability in both healthy and frail older adults, definitive evidence is lacking. Currently data to estimate sample size needs for such a definitive trial to test this hypothesis are insufficient. The LIFE (Lifestyle Interventions for Independence in Elders) study is a pilot, single-blind randomized, controlled trial involving comparison of a physical activity program of moderate intensity to a successful aging program. A total of 400 sedentary persons aged 70-85 years who are at risk of disability are followed for at least one year at four intervention sites. This pilot study will yield the necessary preliminary data to design a definitive Phase 3 randomized, controlled trial. By providing a conclusive answer regarding whether physical activity is effective for preventing major mobility disability or death, the results of the full-scale trial will have relevant clinical and public health implications, and will fill an important gap in knowledge for practicing evidence-based geriatric medicine.
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