This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nearly one in six adults in the United States report having limitations in physical function. That number increases to almost one in two for those over the age of 65 years. Osteoarthritis is the leading cause of impaired function and disability and obesity is a primary risk factor for osteoarthritis, especially in weight-bearing joints. Previous research has shown that a mild-to-moderate weight loss intervention in conjunction with a structured exercise program improves physical function and lessens pain in obese older adults with knee osteoarthritis. Whether more intensive weight loss provides similar benefits as mild weight loss in a younger cohort with impaired function is not known. The purpose of this pilot study is to examine physical function in obese individuals with a BMI > 35.0 kg/m2 following treatment for obesity using laparoscopic Roux-en-Y gastric bypass surgery. It is hypothesized that the greater weight loss associated with this treatment modality will improve physical function. The primary aim to address this hypothesis is to determine self-reported physical function and performance on physical function tasks as a result of weight loss from obesity surgery.
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