This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Previous studies have not correlated leptin, adiponectin, and soluble leptin receptor levels in OA patients with their BMI and body composition, making it difficult to dissect these complex relationships. We propose to examine the levels of these two adipokines and the soluble leptin receptor in individuals with and without OA and at BMI above 30 kg m-2 or below 25 kg/m-2. This is a balanced 2x2 design with a focus on older women, since they have a higher rate of obesity than men in this age group, significantly higher levels of circulating leptin, and they are more often afflicted with knee OA. Furthermore, the relationship between the adipokines and soluble leptin receptor and various parameters associated with metabolic syndrome, including insulin levels, blood lipids, blood pressure, and waist circumference will be made. Because of the increased incidence of osteoporosis and osteopenia in this population, and the role that leptin has in bone metabolism, we will also compare measures of bone density at the hip and lower spine among the 4 groups. Together these analysis should provide insight into the relationship between adipokines, OA, and metabolic syndrome in older women.
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