This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The long term goals of this proposal are to understand the relationship between cerebral blood flow (CBF) and the fMRI blood oxygen level dependent (BOLD) contrast in older adults and to develop simple robust methods that account for these dependent measures in fMRI studies.Advances in functional imaging techniques, particularly functional Magnetic Resonance Imaging (fMRI), have revolutionized studies of human brain function. fMRI relies on local changes in blood flow as a surrogate marker for brain activity, which is known as neurovascular coupling. A fundamental assumption with fMRI studies attempting to identify changes in brain activity between two study populations is that they have similar neurovascular coupling. If this assumption is invalid for any reason (i.e. age, drugs, or disease) then a direct and meaningful comparison of the fMRI results is difficult.
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