Beta-(B)- agonists act via B2 adrenergic receptors (B2AR) in the treatment of asthma to relax bronchial smooth muscle. Effects of B- agonists on other lung cells which express B2AR and their role in asthma is not clear. In this project lung cells are obtained by bronchoscopy to test signal transduction characteristics and answer: Is there an intrinsic defect in B2AR signal transduction in asthma patients' lung cells? Does B-agonist therapy induce desensitization of lung cell B2AR? Do B2AR polymorphisms contribute to signal transduction defects?

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
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