Objective: In anorexia nervosa (AN), nutritional repletion and stability is a vital step toward physical and psychological recovery. Recombinant human growth hormone (rhGH) can promote a positive protein balance in malnourished surgical patients. We hypothesize that rhGH treatment will hasten medical stabilization in AN patients. Study Design: Fifteen patients (14 females/1 male) with AN, ages 12-18 years, were enrolled in a 28-day randomized, double-blind, placebo-controlled study. Patients received rhGH (0.05 mg/kg subcutaneously daily) or an equivalent volume of placebo. The primary outcome measure was time to reach functional stability. We defined functional stability as 2 consecutive days in which the patient did not have an increase in pulse greater than 20 bpm with change from a supine to standing position. All patients received a standard refeeding protocol. Results: Admission body mass index (BMI) was 14.5 kg/m2. The rhGH and placebo groups did not differ significantly in admission weight, BMI or daily caloric intake. No adverse events occurred. Patients treated with rhGH reached functional stability more rapidly than those treated with placebo (median 17 vs. 37 days, p=0.02). Conclusion: Anorexia nervosa patients treated with rhGH during nutritional repletion achieved cardiovascular stability and were discharged more rapidly than those treated with placebo. This resulted in briefer hospitalizations for the rhGH group compared to the placebo controls.

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Natarajan, Girija; Shankaran, Seetha; Laptook, Abbot R et al. (2018) Association between sedation-analgesia and neurodevelopment outcomes in neonatal hypoxic-ischemic encephalopathy. J Perinatol 38:1060-1067
Askie, Lisa M; Darlow, Brian A; Finer, Neil et al. (2018) Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration. JAMA 319:2190-2201
DiFrancesco, Mark W; Shamsuzzaman, Abu; McConnell, Keith B et al. (2018) Age-related changes in baroreflex sensitivity and cardiac autonomic tone in children mirrored by regional brain gray matter volume trajectories. Pediatr Res 83:498-505
Autmizguine, Julie; Tan, Sylvia; Cohen-Wolkowiez, Michael et al. (2018) Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. Pediatr Infect Dis J 37:923-929
Jilling, Tamas; Ambalavanan, Namasivayam; Cotten, C Michael et al. (2018) Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8. Pediatr Res 83:943-953
Lin, Shan; Luo, Roger T; Shrestha, Mahesh et al. (2017) The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment. Blood 130:903-907
Puopolo, Karen M; Mukhopadhyay, Sagori; Hansen, Nellie I et al. (2017) Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis. Pediatrics 140:
Lin, Shan; Ptasinska, Anetta; Chen, Xiaoting et al. (2017) A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program. Blood 130:1213-1222
James, Jennifer; Munson, David; DeMauro, Sara B et al. (2017) Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr 190:118-123.e4
Peralta-Carcelen, Myriam; Carlo, Waldemar A; Pappas, Athina et al. (2017) Behavioral Problems and Socioemotional Competence at 18 to 22 Months of Extremely Premature Children. Pediatrics 139:

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