This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of the study is to provide researchers with a source of normal donor blood products for use in experiments focusing on inherited diseases. Normal healthy donors between the ages of 18 and 40 who meet eligibility criteria are enrolled in the study. Donors complete a medical history questionnaire, which is reviewed by a physician to verify eligibility. Donors undergo a physical exam and blood tests. A stem cell mobilizing agent, granulocyte colony stimulating factor (G-CSF), is given for 4 days prior to the collection of white blood cells. White blood cells are collected through the use of a specialized machine (leukapheresis), which removes the white blood cells from the blood. Once the collection is completed, a complete blood count is drawn to ensure blood counts are within normal range. Donors are compensated for their participation in the study. The product is stored in an IRB approved tissue repository. Cincinnati Children's Hospital Medical Center Investigators that have an IRB approved protocol may request cells from the repository.
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