Abstract

Vitiligo is a dermatologic disorder in which melanocytes are destroyed, but the mechanism of destruction and what leads to it is unknown. Among the many theories proposed for the pathogenesis of this disease is that it is an autoimmune phenomenon. This theory is supported by the discovery of autoantibodies to melanocytes and other pigment cell antigens. This autoantibody is lytic for melanocytes in titers that are highest during the active state of the patients including immunoprecipitation, modified ELISA, ADCC, europium release assay, and more recently a fluorescent antibody technique, utilizing flow cytometry.
The specific aims are: l) to screen the sera of vitiligo patients and control subjects by flow cytometry for autoantibodies to melanocytes and other selected cell lines; 2) to secure blood from patients positive for autoantibody and from negative controls and stimulate their lymphocytes with melanocytes; in vitiligo. Vitiligo patients involved in this study will be examined and followed up in the outpatient facilities of the General Clinical Research Center. Flow cytometry resources will also be fully utilized in this investigation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
1M01RR010284-01A1
Application #
5225850
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Guan, Yue; Roter, Debra L; Erby, Lori H et al. (2017) Disclosing genetic risk of Alzheimer's disease to cognitively impaired patients and visit companions: Findings from the REVEAL Study. Patient Educ Couns 100:927-935
Nandakumar, Priyanka; Lee, Dongwon; Richard, Melissa A et al. (2017) Rare coding variants associated with blood pressure variation in 15?914 individuals of African ancestry. J Hypertens 35:1381-1389
Lieberman, Richard; Armeli, Stephen; Scott, Denise M et al. (2016) FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students. Am J Med Genet B Neuropsychiatr Genet 171:879-87
Christensen, Kurt D; Roberts, J Scott; Whitehouse, Peter J et al. (2016) Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial. Ann Intern Med 164:155-63
Armeli, Stephen; O'Hara, Ross E; Covault, Jon et al. (2016) Episode-specific drinking-to-cope motivation and next-day stress-reactivity. Anxiety Stress Coping 29:673-84

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