This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Despite research initiatives aimed at reducing and eliminating racial/ethnic disparities in health and disease, large disparities continue to exist. Typically researchers have attributed these disparities to diet, smoking and poor health care. While these factors certainly contribute to racial/ethnic disparities in health outcomes and disease, there is a growing literature which shows that in addition to these factors health outcomes are also determined by the dynamic interplay of psychosocial, psychoneuroimmunological, personality, coping (positive and negative), affective, interpersonal, religious, and sociodemographic variables. This research project will examine the validity of a biopsychosocial model of disease and health outcomes in the context of its efficacy inpredicting renal health and disease. To achieve this objective, performance on a battery of neuropsychological, personality, psychophysiological and pyschosocial measure will be compared to indices of immune, endocrine, renal and glucose functions. Participants in this study will include a community-based sample of 300 (150 male and 150 females) African Americans aged 18 and above from the Washington, DC, metropolitan area. this study is also designed to examine the utility of telehealth technology as a tool for modifying behaviors/lifestyles that contribute to impaired renal functions and the progression of this condition to renal disease and it end stage. This intervention study will be designed and implemented during year three and four of this study.
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