The broad goal of this proposal is to explore interrelationships between Hepatitis C Virus (HCV) infection, lymphoproliferation, and autoimmune disease in the pathogenesis of the syndrome of Mixed Cryoglobulinemia (MC). To this end, we will: (1) Assess the prevalence of HCV infection in MC. (2) Obtain HCV-specific human monoclonal antibodies. (3) Develop HCV- specific T-cell lines and clones, and (4) Precisely characterize the responses of select patients with MC being treated with IFN alpha. These studies will provide information relevant to other diseases in which antigen-driven dyspropteinemia or cryoglobulinemia may occur, and extend appreciation of the enlarging spectrum of HCV-associated disease. In addition, the in vivo accts of IFNalpha in this and related disorders will be delineated.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
1M01RR010710-01A1
Application #
6283028
Study Section
Project Start
1998-06-04
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
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