Abstract

The devastating social, medical, and economic effects of alcoholism have intensified the need to understand the neurochemical mechanisms underlying alcohol self administration and dependence. Studies in animals and in vitro systems have produced increasing evidence that the GABA- benzodiazepine receptor complex (GBRC) mediates some of the pharmacological and behavioral effects of ethanol, especially the genetic variability in ethanol response. Furthermore, recent studies from our laboratory in which we have used PET to directly examine regional brain glucose metabolism in the brains of normal male subjects and recently detoxified male alcoholics (Volkow et al. 1993) support the involvement of the GBRC as a neurochemical substrate in alcoholism. Purpose:
Specific aim 1 To investigate the activity of GBRC mediated inhibitory neurotransmission in normal controls and recently detoxified alcoholics;
Specific aim 2 To examine the influence of the time period of alcohol withdrawal on GBRC mediated inhibitory neurotransmission;
Specific aim 3 To examine the influence of the time period of alcohol withdrawal on regional brain glucose metabolism during baseline.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
1M01RR010710-01A1
Application #
6283038
Study Section
Project Start
1998-06-04
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Lima, Fabio V; Gruberg, Luis; Aslam, Usman et al. (2018) The impact of unfractionated heparin or bivalirudin on patients with stable coronary artery disease undergoing percutaneous coronary intervention. J Interv Cardiol 31:177-184
Cornelius, Talea; Birk, Jeffrey L; Edmondson, Donald et al. (2018) The joint influence of emotional reactivity and social interaction quality on cardiovascular responses to daily social interactions in working adults. J Psychosom Res 108:70-77
Edmondson, Donald; Sumner, Jennifer A; Kronish, Ian M et al. (2018) The Association of Posttraumatic Stress Disorder With Clinic and Ambulatory Blood Pressure in Healthy Adults. Psychosom Med 80:55-61
Parisette-Sparks, Alyssa; Bufferd, Sara J; Klein, Daniel N (2017) Parental Predictors of Children's Shame and Guilt at Age 6 in a Multimethod, Longitudinal Study. J Clin Child Adolesc Psychol 46:721-731
Barrios, Chelsey S; Bufferd, Sara J; Klein, Daniel N et al. (2017) The interaction between parenting and children's cortisol reactivity at age 3 predicts increases in children's internalizing and externalizing symptoms at age 6. Dev Psychopathol 29:1319-1331
Farmer, Cristan A; Epstein, Jeffery N; Findling, Robert L et al. (2017) Risperidone Added to Psychostimulant in Children with Severe Aggression and Attention-Deficit/Hyperactivity Disorder: Lack of Effect on Attention and Short-Term Memory. J Child Adolesc Psychopharmacol 27:117-124
Findling, Robert L; Townsend, Lisa; Brown, Nicole V et al. (2017) The Treatment of Severe Childhood Aggression Study: 12 Weeks of Extended, Blinded Treatment in Clinical Responders. J Child Adolesc Psychopharmacol 27:52-65
Wang, Y Claire; Shimbo, Daichi; Muntner, Paul et al. (2017) Prevalence of Masked Hypertension Among US Adults With Nonelevated Clinic Blood Pressure. Am J Epidemiol 185:194-202
Jurgens, Corrine Y; Lee, Christopher S; Riegel, Barbara (2017) Psychometric Analysis of the Heart Failure Somatic Perception Scale as a Measure of Patient Symptom Perception. J Cardiovasc Nurs 32:140-147
Broderick, Joan E; Keefe, Francis J; Schneider, Stefan et al. (2016) Cognitive behavioral therapy for chronic pain is effective, but for whom? Pain 157:2115-23

Showing the most recent 10 out of 283 publications