Abstract

SPECIFIC AIMS 1. To compare the effect of oral hypoglycemic agents Glipizide-GITS and Metformin alone or in combination on hepatic glucose production in patients with NIDDM. 2. To compare insulin secretory responses to Sustacal in patients with NIDDM receiving Glipizide-GITS or Metformin alone or in combination. It is the hypothesis of this proposal that the combination of an oral hypoglycemic agent that improves insulin secretion (Glipizide) with one that improves insulin action (Metformin) in the treatment regiment of NIDDM patients will provide improved glycemia compared to either agent alone through a synergistic effect on insulin secretion and action.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR010710-02
Application #
6123137
Study Section
Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Lima, Fabio V; Gruberg, Luis; Aslam, Usman et al. (2018) The impact of unfractionated heparin or bivalirudin on patients with stable coronary artery disease undergoing percutaneous coronary intervention. J Interv Cardiol 31:177-184
Cornelius, Talea; Birk, Jeffrey L; Edmondson, Donald et al. (2018) The joint influence of emotional reactivity and social interaction quality on cardiovascular responses to daily social interactions in working adults. J Psychosom Res 108:70-77
Edmondson, Donald; Sumner, Jennifer A; Kronish, Ian M et al. (2018) The Association of Posttraumatic Stress Disorder With Clinic and Ambulatory Blood Pressure in Healthy Adults. Psychosom Med 80:55-61
Parisette-Sparks, Alyssa; Bufferd, Sara J; Klein, Daniel N (2017) Parental Predictors of Children's Shame and Guilt at Age 6 in a Multimethod, Longitudinal Study. J Clin Child Adolesc Psychol 46:721-731
Barrios, Chelsey S; Bufferd, Sara J; Klein, Daniel N et al. (2017) The interaction between parenting and children's cortisol reactivity at age 3 predicts increases in children's internalizing and externalizing symptoms at age 6. Dev Psychopathol 29:1319-1331
Farmer, Cristan A; Epstein, Jeffery N; Findling, Robert L et al. (2017) Risperidone Added to Psychostimulant in Children with Severe Aggression and Attention-Deficit/Hyperactivity Disorder: Lack of Effect on Attention and Short-Term Memory. J Child Adolesc Psychopharmacol 27:117-124
Findling, Robert L; Townsend, Lisa; Brown, Nicole V et al. (2017) The Treatment of Severe Childhood Aggression Study: 12 Weeks of Extended, Blinded Treatment in Clinical Responders. J Child Adolesc Psychopharmacol 27:52-65
Wang, Y Claire; Shimbo, Daichi; Muntner, Paul et al. (2017) Prevalence of Masked Hypertension Among US Adults With Nonelevated Clinic Blood Pressure. Am J Epidemiol 185:194-202
Jurgens, Corrine Y; Lee, Christopher S; Riegel, Barbara (2017) Psychometric Analysis of the Heart Failure Somatic Perception Scale as a Measure of Patient Symptom Perception. J Cardiovasc Nurs 32:140-147
Gadow, Kenneth D; Brown, Nicole V; Arnold, L Eugene et al. (2016) Severely Aggressive Children Receiving Stimulant Medication Versus Stimulant and Risperidone: 12-Month Follow-Up of the TOSCA Trial. J Am Acad Child Adolesc Psychiatry 55:469-78

Showing the most recent 10 out of 283 publications