Abstract

The primary goal of this project is to characterize Lyme encepahlopathy. The case group includes patients with late untreated disseminated infection and chronic Lyme patients with post treatment syndromes 3 or more months following completion of antibiotic treatment (n=100). The first control group will consist of 100 population based healthy individuals who will be compared to case group regarding neurobehavioral measures. The second control group will consist of the CSF specimens from 50 other Neurologic Disease (OND) Controls which will be served as a quality control for the CSF measures performed on the case groups. By defining the clinical features and pathophysiology of Bb associated encephalopathy, rational treatment strategies can be designed. This project involves an 18 month longitudinal evaluation of late untreated disseminated Bb infection and post Lyme syndrome (n=100).
The Specific Aims are: 1. To define the neurobehavioral and psychological sequelae of chronic Lyme disease. 2. To determine the pathogenesis for neurobehavioral deficits in chronic Lyme disease. 3. To identify the clinical and laboratory factors which predict health outcome in chronic Lyme disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR010710-04
Application #
6444742
Study Section
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
4
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Lima, Fabio V; Gruberg, Luis; Aslam, Usman et al. (2018) The impact of unfractionated heparin or bivalirudin on patients with stable coronary artery disease undergoing percutaneous coronary intervention. J Interv Cardiol 31:177-184
Cornelius, Talea; Birk, Jeffrey L; Edmondson, Donald et al. (2018) The joint influence of emotional reactivity and social interaction quality on cardiovascular responses to daily social interactions in working adults. J Psychosom Res 108:70-77
Edmondson, Donald; Sumner, Jennifer A; Kronish, Ian M et al. (2018) The Association of Posttraumatic Stress Disorder With Clinic and Ambulatory Blood Pressure in Healthy Adults. Psychosom Med 80:55-61
Parisette-Sparks, Alyssa; Bufferd, Sara J; Klein, Daniel N (2017) Parental Predictors of Children's Shame and Guilt at Age 6 in a Multimethod, Longitudinal Study. J Clin Child Adolesc Psychol 46:721-731
Barrios, Chelsey S; Bufferd, Sara J; Klein, Daniel N et al. (2017) The interaction between parenting and children's cortisol reactivity at age 3 predicts increases in children's internalizing and externalizing symptoms at age 6. Dev Psychopathol 29:1319-1331
Farmer, Cristan A; Epstein, Jeffery N; Findling, Robert L et al. (2017) Risperidone Added to Psychostimulant in Children with Severe Aggression and Attention-Deficit/Hyperactivity Disorder: Lack of Effect on Attention and Short-Term Memory. J Child Adolesc Psychopharmacol 27:117-124
Findling, Robert L; Townsend, Lisa; Brown, Nicole V et al. (2017) The Treatment of Severe Childhood Aggression Study: 12 Weeks of Extended, Blinded Treatment in Clinical Responders. J Child Adolesc Psychopharmacol 27:52-65
Wang, Y Claire; Shimbo, Daichi; Muntner, Paul et al. (2017) Prevalence of Masked Hypertension Among US Adults With Nonelevated Clinic Blood Pressure. Am J Epidemiol 185:194-202
Jurgens, Corrine Y; Lee, Christopher S; Riegel, Barbara (2017) Psychometric Analysis of the Heart Failure Somatic Perception Scale as a Measure of Patient Symptom Perception. J Cardiovasc Nurs 32:140-147
Breen, Michael S; Beliakova-Bethell, Nadejda; Mujica-Parodi, Lilianne R et al. (2016) Acute psychological stress induces short-term variable immune response. Brain Behav Immun 53:172-182

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