This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Valid measures of functioning are essential if one is to test new behavioral hypothesis in CFS. Specifically, a number of descriptive, naturalistic outcome, illness comparison, clinical outcome, and epidemiological studies suggest that two subsets of CFS patients can be delineated by physical and role functioning, CFS symptom severity and psychiatric symptomatology. These putative subsets, as proposed in this application, include a low functioning , high psychiatric co-morbidity group(Group 1)and a high functioning, low psychiatric co-morbidity group (Group 2). Group 1 patients will have a clinical presentation similar to somaticized depression, while Group 2 patients will resemble individuals with fatiguing medical conditions such as multiple sclerosis (MS). This proposal seeks to establish the validity of this subgrouping scheme and to examine it's influence on clinical outcomes.
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