This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this proposal is to identify the underlying genetic causes of MS. Specifically, the current investigation seeks to assess genetic factors related to early-onset Multiple Sclerosis (MS). A vast body of previous research conclusively shows that there is a strong genetic influence on MS. Genes in their germline configuration influence susceptibility, disease progression and most likely, also response to treatment. Despite this evidence, it has been difficult to identify the specific genes involved. Previous work has looked at known genes thought to be candidates for having influence on MS - for example, genes that control immune system function and resistance to viral infection - but this approach has met with partial success. The technology now exists to identify the genes that cause MS susceptibility using unbiased and efficient methods. Identification of the exact molecular basis of MS susceptibility will undoubtedly result in new opportunities for treatment and/or prevention of this cruel disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR010710-12
Application #
7950801
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-12-01
Project End
2009-11-30
Budget Start
2008-12-01
Budget End
2009-11-30
Support Year
12
Fiscal Year
2009
Total Cost
$11,414
Indirect Cost
Name
State University New York Stony Brook
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
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