This study is designed to evaluate the safety of vigabatrin as monotherapy in adult patients with complex partial epilepsy. In addition, continued efficacy of vigabatrin as a monotherapy will be evaluated. Vigabatrin causes suppression of seizure incidence in complex partial seizure models (kindling, pilocarpine) and generalized tonic-clonic seizure models (audiogenic, photic, seizure-prone gerbil, hyperbaric oxygen, maximal electroshock, and chemically-induced models). Vigabatrin had both proconvulsant and anticonvulsant efects in a generalized absence model (seizure-prone rats). Seizure symptoms were exacerbated after electrical stimulation of the spinal cord. These results suggest that vigabatrin is particularly effective in generalized convulsive seizure models and partial complex models. The anti- convulsant effect of vigabatrin is potentiated by the inhibitory neurotransmitter glycine. Clinical trials have shown that the addition of vigabatrin to standard antiepilepsy therapy significantly decreases seizure frequency and severity in patients with focal epilepsy whose seizures have been difficult to control. Efficacy results in 'add-on' trials, coupled with a favorable safety profile suggest vigabatrin be studies as a monotherapy.
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Quick, Virginia; Byrd-Bredbenner, Carol; Shoff, Suzanne et al. (2016) Relationships of Sleep Duration With Weight-Related Behaviors of U.S. College Students. Behav Sleep Med 14:565-80 |
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