Charcot Neuroarthropathy (CN) is a degenerative disease of denervated joints that is most frequently encountered in the feet of patients with diabetic neuropathy. Little is known about etiopathogenesis of CN in diabetes other than that it is usually preceded by the development of moderate to dense diabetic neuropathy and involves a remodeling of bone tissue in the affected foot, usually in the vicinty of several anatomically related joints. Symptoms of CN are usually first notedafter an incident of acute trauma to the foot after which bony disintegration, most often in the tarsal or talonavicular regions, is identifiable by plain radiography. The goal of the present study is to determine if the active bone remodeling found among Cn neuropathic diabetic patients is precipitated by the active CN disease or begins prior to CN fractures. Therefore, we propose to monitor markers of bone remodeling in non-CN neuropathic diabetic patients to determine if any indication of bone remodeling and/or bone disease can be detected among this at-risk population prior to the onset of an active CN process. This study is specifically designed to collect single time-point data on selected biochemical markers of bone regulation and metabolism (Osteocalcin, Collagen, Telopeptides, and Interleukin 1-beta) to determine if patients at risk for CN by virtue of having dense diabetic neuropathy and autonomic neuropathy already show evidence of abnormal bone metabolism prior to actually developing a Charcot fracture.
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Lewis, Mechelle M; Flynn, Michael R; Lee, Eun-Young et al. (2016) Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders. Neurotoxicology 57:39-44 |
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