Elevation of red blood cell count (post -transplant erythrocytosis-PTE) develops in more than 15% of kidney transplant recipients, generally within two years after transplant. PTE may potentially increase the risk of thrombosis in vital organs. The cause of PTE is uncertain and may be due to signaling between erythropoietin and angiotensin. Erythropoietin is a protein growth factor produced by the kidneys that is required for the production of red blood cells. Recent studies suggest that another protein, angiotensin and its receptor appear to play a role in the pathogenesis of PTE. Others have shown that inhibition of angiotensin converting enzyme reduces circulating erythropoietin and angiotensin signaling pathways may be an important part of the mechanism of PTE. Our objective is to examine the signal transduction pathways through which angiotensin modulates red blood cell proliferation and the mechanism by which these pathways contribute to PTE. Blood will be drawn from 45 adults. The blood will be processed and studied to determine a) the expression of angiotensin receptor in red blood cell precursor from patients with PTE; b) the proliferative response of red blood cell progenitors from patients with or without PTE to angiotensin; and c) the plasma level of Ac-SDPK (a factor involved in red blood cell production) in patients with PTE.
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
| Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208 |
| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917 |
| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Quick, Virginia; Byrd-Bredbenner, Carol; Shoff, Suzanne et al. (2016) Relationships of Sleep Duration With Weight-Related Behaviors of U.S. College Students. Behav Sleep Med 14:565-80 |
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