This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to characterize the steroid level profile throughout the menstrual cycle in Black females compared to White females, and to monitor the effects of obesity and race on sex steroid levels and bone mineral density and architecture. There appears to be strong and increasing evidence that there are fundamental differences in circulating sex steroid levels, which contribute to a multitude of end organ changes in Blacks. We propose to document these in greater detail, above all accounting for differences in obesity between racial groups. Additionally there has been nothing but descriptive studies to date, and little exploration of potential mechanisms. In this study 200 normally cycling females of Black and White origin will be studied. We will intensively study the menstrual cycle with daily urinary collections, and for one cycle blood draws and ultrasound documentation of follicular development. We will characterize circulating sex steroid during the course of the menstrual cycle. Additionally we will examine body composition and bone mineral density and architecture in this group. We will also collect serum so that we can look at insulin resistance, cardiovascular risks, DNA, and serum for proteomics in this cohort. We propose to establish normative data for sex hormone levels in Black women with a history of regular menstrual cycles and compare these with their White counterparts. Three consecutive menstrual cycles will be studied in women who are of normal body weight, height, and BMI. These data will serve as our primary outcome. We also propose to measure sex hormone levels in obese Black and White women, collect serum for the future so we can look at insulin resistance, cardiovascular risks, DNA and serum proteomics, and in all groups bone mineral density and architecture will be calculated.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
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National Center for Research Resources Initial Review Group (RIRG)
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Pennsylvania State University
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United States
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Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561
Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580
Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159
Lee, Soomi; Martire, Lynn M; Damaske, Sarah A et al. (2018) Covariation in couples' nightly sleep and gender differences. Sleep Health 4:201-208
Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167
Liu, Guodong; Sterling, Nicholas W; Kong, Lan et al. (2017) Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database. Mov Disord 32:913-917
Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108
Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523
Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344
Lewis, Mechelle M; Flynn, Michael R; Lee, Eun-Young et al. (2016) Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders. Neurotoxicology 57:39-44

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