This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Obstructive sleep apnea secondary to perennial allergic rhinitis is a relatively common sleep disorder that induces daytime sleepiness and symptoms of deprived sleep leading to depression, irritability, lowered cognitive performance, increased likelihood of accidents and higher rates of morbidity and mortality. This disorder is characterized by recurrent episodes of partial or complete upper airway obstruction during sleep particularly during allergy season. The involvement of upper airway obstruction can be seen using overnight polysomnography in a sleep lab setting. Treatment of the perennial allergic rhinitis involves the use of steroids delivered by nasal spray that reduce the nasal symptoms associated with rhinitis. This study is aimed at assessing the effects of an FDA approved nasal spray (Mometasone Furoate, Nasonex) on subjects with mild to moderate obstructive sleep apnea-Hypopnea syndrome associated with perennial allergic rhinitis to determine if this nasal spray will both improve year round allergy symptoms and reduce the magnitude of sleep disordered breathing as determined by polysomnography.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR010732-14
Application #
7718811
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2008-04-01
Project End
2009-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
14
Fiscal Year
2008
Total Cost
$12,576
Indirect Cost
Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
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