This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is about the search for the perfect fat, i.e. one that is trans fat-free but low is in saturated fatty acids. The PI proposes that a palm DAG may be an excellent choice. The hypothesis is that the modified fat (either palm DAG or palm kernel DAG), compared to the parent fat will result in a higher HDL-C, lower LDL-C, and lower LDL-C/HDL-C ratio, as well as potentially lower TG levels. A diet of 15 g/day of the palm or palm kernel DAG fat will be tested against the parent, unmodified palm or palm kernel fat. The study will be a randomized, 2-period, blinded cross-over design. A control background diet will be used throughout the feeding periods. Participants will include healthy men and women, 30-60 years of age, with moderately elevated LDL-C (120-175 mg/dL) and with HDL-C of 30-50 mg/dL and triglycerides of 120-350 mg/dL.
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| Almeida, David M; Lee, Soomi; Walter, Kimberly N et al. (2018) The effects of a workplace intervention on employees' cortisol awakening response. Community Work Fam 21:151-167 |
| Lieberman, Jay L; DE Souza, Mary Jane; Wagstaff, David A et al. (2018) Menstrual Disruption with Exercise Is Not Linked to an Energy Availability Threshold. Med Sci Sports Exerc 50:551-561 |
| Zhang, Lijun; Wang, Ming; Sterling, Nicholas W et al. (2018) Cortical Thinning and Cognitive Impairment in Parkinson's Disease without Dementia. IEEE/ACM Trans Comput Biol Bioinform 15:570-580 |
| Rossi, Alexander; Berger, Kristin; Chen, Honglei et al. (2018) Projection of the prevalence of Parkinson's disease in the coming decades: Revisited. Mov Disord 33:156-159 |
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| Sterling, Nicholas W; Du, Guangwei; Lewis, Mechelle M et al. (2017) Cortical gray and subcortical white matter associations in Parkinson's disease. Neurobiol Aging 49:100-108 |
| Berryman, Claire E; Fleming, Jennifer A; Kris-Etherton, Penny M (2017) Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. J Nutr 147:1517-1523 |
| Calhoun, Susan L; Fernandez-Mendoza, Julio; Vgontzas, Alexandros N et al. (2017) Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol 45:337-344 |
| Quick, Virginia; Byrd-Bredbenner, Carol; Shoff, Suzanne et al. (2016) Relationships of Sleep Duration With Weight-Related Behaviors of U.S. College Students. Behav Sleep Med 14:565-80 |
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