Abstract

Determination of Mechanisms of Hyperestrogenemia in Perimenopausal Women. This experiment will study a total of 90 women. Fifty will be perimenopausal and 40 will be midreproductive aged (strict definitions will be used, based upon the PI's previous data). Serial ultrasound studies will be performed to characterize ovarian morphology up to and immediately beyond ovulation. In a subset of women (12 midreproductive aged and 20 perimenopausal), daily serum sampling will be performed to assess the patterns of LH, FSH, estradiol, progesterone and inhibin A and B and activin A and B secretion, as these are the hypothesized peptides that regulate FSH. This study is approximately 25% completed at this point, and has been chiefly hampered by slow recruitment. As we now seem to have discovered an effective way to recruit women, we plan to complete this study within the coming year.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR012248-04
Application #
6408694
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1997-09-30
Project End
2001-11-30
Budget Start
Budget End
Support Year
4
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Ezzati, Ali; Katz, Mindy J; Lipton, Michael L et al. (2016) Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults. Brain Imaging Behav 10:652-9
Huang, Ying; Van Horn, Linda; Tinker, Lesley F et al. (2014) Measurement error corrected sodium and potassium intake estimation using 24-hour urinary excretion. Hypertension 63:238-44
Mossavar-Rahmani, Yasmin; Tinker, Lesley F; Huang, Ying et al. (2013) Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative. Nutr J 12:63
Esterson, Yonah B; Zhang, Kehao; Koppaka, Sudha et al. (2013) Insulin sensitizing and anti-inflammatory effects of thiazolidinediones are heightened in obese patients. J Investig Med 61:1152-60
Prentice, Ross L; Neuhouser, Marian L; Tinker, Lesley F et al. (2013) An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 22:2374-83
Wylie-Rosett, Judith; Aebersold, Karin; Conlon, Beth et al. (2013) Health effects of low-carbohydrate diets: where should new research go? Curr Diab Rep 13:271-8
Cai, Guiqing; Atzmon, Gil; Naj, Adam C et al. (2012) Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer disease. Neurobiol Aging 33:416-417.e3
Wang, Zhaoming; Parikh, Hemang; Jia, Jinping et al. (2012) Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry. Hum Genet 131:1173-85
Kenny, Eimear E; Pe'er, Itsik; Karban, Amir et al. (2012) A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet 8:e1002559
Kehlenbrink, S; Koppaka, S; Martin, M et al. (2012) Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis. Diabetologia 55:3021-8

Showing the most recent 10 out of 150 publications