This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator. This proposal involves creation of a functional model of xenografted human endometrium. We collect endometrial biopsy tissue from female volunteers ages 18-45 for implantation into laboratory mice. The goal is to study drugs or other agents that have been successfully used to elucidate mechanisms of hormonal interplay in the rodent endometrium but cannot be practically given to human subjects. We have been able to successfully implant human endometrium under the mouse renal capsule and show tissue proliferation 4-6 weeks after engraftment. Currently, we are testing a novel pathway of endometrial cell cycle regulation that has been recently characterized in the mouse endometrium. If successful, this project may provide with a possible springboard for development of targeted inhibitors of estrogen-induced pre-cancerous uterine growth.
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