Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The primary objective of this study is to determine if a less invasive method other than liver biopsy can be used to diagnose non-alcoholic steatohepatitis with an acceptable sensitivity and specificity when compared to the gold standard of liver biopsy. Our secondary objective is to determine if these same less invasive methods can be used to determine the grade of non-alcoholic steatohepatitis and the stage of fibrosis. We hypothesize that by using 99mTc-mebrofenin scintigraphy scan to determine necroinflammation and measuring homocysteine levels we will be able to determine the diagnosis of non-alcoholic steatohepatitis, the grade of steatohepatitis, and the stage of fibrosis as compared to the gold standard of liver biopsy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR012248-12
Application #
7717620
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Project Start
2007-12-01
Project End
2008-05-31
Budget Start
2007-12-01
Budget End
2008-05-31
Support Year
12
Fiscal Year
2008
Total Cost
$2,532
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Ezzati, Ali; Katz, Mindy J; Lipton, Michael L et al. (2016) Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults. Brain Imaging Behav 10:652-9
Huang, Ying; Van Horn, Linda; Tinker, Lesley F et al. (2014) Measurement error corrected sodium and potassium intake estimation using 24-hour urinary excretion. Hypertension 63:238-44
Mossavar-Rahmani, Yasmin; Tinker, Lesley F; Huang, Ying et al. (2013) Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative. Nutr J 12:63
Esterson, Yonah B; Zhang, Kehao; Koppaka, Sudha et al. (2013) Insulin sensitizing and anti-inflammatory effects of thiazolidinediones are heightened in obese patients. J Investig Med 61:1152-60
Prentice, Ross L; Neuhouser, Marian L; Tinker, Lesley F et al. (2013) An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer. Cancer Epidemiol Biomarkers Prev 22:2374-83
Wylie-Rosett, Judith; Aebersold, Karin; Conlon, Beth et al. (2013) Health effects of low-carbohydrate diets: where should new research go? Curr Diab Rep 13:271-8
Kenny, Eimear E; Pe'er, Itsik; Karban, Amir et al. (2012) A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet 8:e1002559
Kehlenbrink, S; Koppaka, S; Martin, M et al. (2012) Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis. Diabetologia 55:3021-8
Sinai, Anthony P; Kaneshiro, Edna S; Ward, Honorine et al. (2012) The state of research for AIDS-associated opportunistic infections and the importance of sustaining smaller research communities. Eukaryot Cell 11:90-7
Huffman, Derek M; Deelen, Joris; Ye, Kenny et al. (2012) Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. J Gerontol A Biol Sci Med Sci 67:1153-60

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