Abstract

The primary objectives of this study are to determine the maximum tolerated dose for TAC-101 in patients with malignancies unresponsive to standard therapy or for which there is no standard treatment, and to evaluate the safety of chronic daily adminisstration of TAC-101. Secondary objectives are to study the pharmacokinetics of TAC-101 in patients with cancer, and to detect any evidence of antitumor activity of TAC-101. This escalating study will enroll three subjects per dose level, with 6 subjects at the maximum tolerated dose.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR013297-02
Application #
6409334
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1999-09-20
Project End
2003-11-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Type
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Wang, Jin; You, Xiaozhen; Wu, Wensong et al. (2014) Classification of fMRI patterns--a study of the language network segregation in pediatric localization related epilepsy. Hum Brain Mapp 35:1446-60
Sun, Binjian; Berl, Madison M; Burns, Thomas G et al. (2013) Age association of language task induced deactivation induced in a pediatric population. Neuroimage 65:23-33
Hsu, Ping-Ching; Zhou, Bin; Zhao, Yi et al. (2013) Feasibility of identifying the tobacco-related global metabolome in blood by UPLC-QTOF-MS. J Proteome Res 12:679-91
You, Xiaozhen; Adjouadi, Malek; Wang, Jin et al. (2013) A decisional space for fMRI pattern separation using the principal component analysis--a comparative study of language networks in pediatric epilepsy. Hum Brain Mapp 34:2330-42
Tractenberg, Rochelle E; Yumoto, Futoshi; Aisen, Paul S et al. (2012) Using the Guttman scale to define and estimate measurement error in items over time: the case of cognitive decline and the meaning of ""points lost"". PLoS One 7:e30019
Hartmaier, R J; Richter, A S; Gillihan, R M et al. (2012) A SNP in steroid receptor coactivator-1 disrupts a GSK3? phosphorylation site and is associated with altered tamoxifen response in bone. Mol Endocrinol 26:220-7
Strang, John F; Kenworthy, Lauren; Daniolos, Peter et al. (2012) Depression and Anxiety Symptoms in Children and Adolescents with Autism Spectrum Disorders without Intellectual Disability. Res Autism Spectr Disord 6:406-412
Spurney, Christopher F; Rocha, Carolina Tesi; Henricson, Erik et al. (2011) CINRG pilot trial of coenzyme Q10 in steroid-treated Duchenne muscular dystrophy. Muscle Nerve 44:174-8
Yerys, Benjamin E; Wallace, Gregory L; Jankowski, Kathryn F et al. (2011) Impaired Consonant Trigrams Test (CTT) performance relates to everyday working memory difficulties in children with autism spectrum disorders. Child Neuropsychol 17:391-9
Merhar, Stephanie L; Schibler, Kurt R; Sherwin, Catherine M et al. (2011) Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatr 159:152-154.e3

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