Abstract

This is an open, placebo-controlled, randomized crossover study of the effects of itraconazole on the metabolism of oxymetholone. eight normal, healthy male subjects will be studied over 25 days. The primary objectives are to determine the human pharmacokinetics of oxymetholone, and to determine if oxymetholone is metabolized by the cytochrome P450 system in the human liver. To make this determination, itraconazole (a known inhibitor of the most abundant cytochrome p450 isoform, CYP3A4) will be administered to the subjects to determine its effect on the metabolism of oxymetholone in the human body.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR013297-02S1
Application #
6427912
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Type
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Wang, Jin; You, Xiaozhen; Wu, Wensong et al. (2014) Classification of fMRI patterns--a study of the language network segregation in pediatric localization related epilepsy. Hum Brain Mapp 35:1446-60
Hsu, Ping-Ching; Zhou, Bin; Zhao, Yi et al. (2013) Feasibility of identifying the tobacco-related global metabolome in blood by UPLC-QTOF-MS. J Proteome Res 12:679-91
You, Xiaozhen; Adjouadi, Malek; Wang, Jin et al. (2013) A decisional space for fMRI pattern separation using the principal component analysis--a comparative study of language networks in pediatric epilepsy. Hum Brain Mapp 34:2330-42
Sun, Binjian; Berl, Madison M; Burns, Thomas G et al. (2013) Age association of language task induced deactivation induced in a pediatric population. Neuroimage 65:23-33
Tractenberg, Rochelle E; Yumoto, Futoshi; Aisen, Paul S et al. (2012) Using the Guttman scale to define and estimate measurement error in items over time: the case of cognitive decline and the meaning of ""points lost"". PLoS One 7:e30019
Hartmaier, R J; Richter, A S; Gillihan, R M et al. (2012) A SNP in steroid receptor coactivator-1 disrupts a GSK3? phosphorylation site and is associated with altered tamoxifen response in bone. Mol Endocrinol 26:220-7
Strang, John F; Kenworthy, Lauren; Daniolos, Peter et al. (2012) Depression and Anxiety Symptoms in Children and Adolescents with Autism Spectrum Disorders without Intellectual Disability. Res Autism Spectr Disord 6:406-412
You, Xiaozhen; Adjouadi, Malek; Guillen, Magno R et al. (2011) Sub-patterns of language network reorganization in pediatric localization related epilepsy: a multisite study. Hum Brain Mapp 32:784-99
Spurney, Christopher F; Rocha, Carolina Tesi; Henricson, Erik et al. (2011) CINRG pilot trial of coenzyme Q10 in steroid-treated Duchenne muscular dystrophy. Muscle Nerve 44:174-8
Yerys, Benjamin E; Wallace, Gregory L; Jankowski, Kathryn F et al. (2011) Impaired Consonant Trigrams Test (CTT) performance relates to everyday working memory difficulties in children with autism spectrum disorders. Child Neuropsychol 17:391-9

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