Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goals of this study are to describe the characteristics of P50 auditory evoked potentials (AEP) in patients with chronic low back pain (CLBP). Dysregulation of the ascending reticular activating system (ARAS) has been implicated in several psychiatric and sleep disorders. Measurement of activity of the ARAS can be obtained from the characteristics of the P50 AEP.
Specific Aim 1. To describe the characteristic of the P50 AEP in patients with CLBP with and without depression and sleep disturbances.
Specific Aim 2. To correlate the latency and amplitude of the P50 AEP with the amount of pain in patients with CLBP as assessed by the McGill Pain Questionnaire-Short Form.
Specific Aim 3. To correlate the latency and amplitude of the P50 AEP with the amount of depression in patients with CLBP as assessed by the Depression-Arkansas Questionnaire.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR014288-08
Application #
7377662
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-04-01
Project End
2007-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
8
Fiscal Year
2006
Total Cost
$716
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

Serra, Monica C; Blumenthal, Jacob B; Addison, Odessa R et al. (2017) Effects of Weight Loss with and without Exercise on Regional Body Fat Distribution in Postmenopausal Women. Ann Nutr Metab 70:312-320
Grams, Morgan E; Yang, Wei; Rebholz, Casey M et al. (2017) Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 70:337-346
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2015) Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults. J Gerontol A Biol Sci Med Sci 70:91-6
Coker, Robert H; Hays, Nicholas P; Williams, Rick H et al. (2014) Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults. J Gerontol A Biol Sci Med Sci 69:363-70
Herrick, Jeffrey E; Bliwise, Donald L; Puri, Shipra et al. (2014) Strength training and light physical activity reduces the apnea-hypopnea index in institutionalized older adults. J Am Med Dir Assoc 15:844-6
Conley, Travis B; McCabe, George P; Lim, Eunjung et al. (2013) Age and sex affect protein metabolism at protein intakes that span the range of adequacy: comparison of leucine kinetics and nitrogen balance data. J Nutr Biochem 24:693-9
Mondal, Ashis K; Sharma, Neeraj K; Elbein, Steven C et al. (2013) Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Physiol Genomics 45:509-20
Sharma, Neeraj K; Langberg, Kurt A; Mondal, Ashis K et al. (2013) Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLoS One 8:e65303
Finlin, Brian S; Bodles-Brakhop, Angela M; Yao-Borengasser, Aiwei et al. (2012) Regulation of small ubiquitin-like modifier-1, nuclear receptor coreceptor, histone deacetylase 3, and peroxisome proliferator-activated receptor-? in human adipose tissue. Metab Syndr Relat Disord 10:312-7
Cane, Stefania; Ponnappan, Subramaniam; Ponnappan, Usha (2012) Impairment of non-muscle myosin IIA in human CD4+ T cells contributes to functional deficits in the elderly. Cell Mol Immunol 9:86-96

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