This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goals of this study are to describe the characteristics of P50 auditory evoked potentials (AEP) in patients with chronic low back pain (CLBP). Dysregulation of the ascending reticular activating system (ARAS) has been implicated in several psychiatric and sleep disorders. Measurement of activity of the ARAS can be obtained from the characteristics of the P50 AEP.
Specific Aim 1. To describe the characteristic of the P50 AEP in patients with CLBP with and without depression and sleep disturbances.
Specific Aim 2. To correlate the latency and amplitude of the P50 AEP with the amount of pain in patients with CLBP as assessed by the McGill Pain Questionnaire-Short Form.
Specific Aim 3. To correlate the latency and amplitude of the P50 AEP with the amount of depression in patients with CLBP as assessed by the Depression-Arkansas Questionnaire.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
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National Center for Research Resources Initial Review Group (RIRG)
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University of Arkansas for Medical Sciences
Schools of Medicine
Little Rock
United States
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