This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypothesis #1: High-intensity progressive resistance training (PRT) will increase strength and muscle mass, reduce fatigue and improve quality of life , while the low-intensity non-progressive resistance training group will have reduced strength and muscle mass, with no change in fatigue or quality of life. Hypothesis #2: Muscle protein synthesis will be greatly decreased as a result of testosterone ablation. A single bout of resistance exercise will result in an increase in the rate of muscle protein synthesis in both groups, although the increase will be greater in the high resistance group than the low resistance group. Hypothesis #3: The increase in the rate of muscle protein synthesis from the single bout of resistance exercise will predict the hypertrophic response to the subsequent progressive resistance strength training program.
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